There are several parts of the Constitution that have a significant impact on business. Here are a few examples:

The Commerce Clause (Article I, Section 8, Clause 3): This clause grants Congress the power to regulate interstate commerce, which has a significant impact on businesses that operate across state lines or engage in interstate transactions. This clause has been interpreted broadly by the courts and has been used to justify a wide range of federal regulatory programs that affect businesses, including antitrust laws, consumer protection laws, and environmental regulations.

The Due Process Clauses (Fifth and Fourteenth Amendments): These clauses protect individuals from being deprived of life, liberty, or property without due process of law. The Due Process Clauses have been used to challenge government regulations that are deemed to be overly burdensome or arbitrary, and they also protect the right to enter into contracts, which is an essential aspect of business activity.

The Takings Clause (Fifth Amendment): This clause prohibits the government from taking private property for public use without just compensation. The Takings Clause has been used to challenge government regulations that are deemed to have a significant impact on the value of private property, including land-use regulations and eminent domain actions.

The Equal Protection Clause (Fourteenth Amendment): This clause prohibits the government from denying equal protection of the laws to any person within its jurisdiction. The Equal Protection Clause has been used to challenge discriminatory practices by businesses, including those that are based on race, gender, religion, or other protected characteristics.

Overall, these and other provisions of the Constitution play a crucial role in shaping the legal environment in which businesses operate and in protecting the rights of businesses and their stakeholders.